WebFeb 17, 2024 · In vitro studies revealed that maltol protected SH‑SY5Y cells against OGD‑induced chromatinolysis by inhibiting two reactive oxygen species (ROS)‑regulated pathways. One was DNA double‑strand breaks and the other was nuclear translocation of apoptosis inducing factor. Mechanistically, maltol not only inhibited OGD‑induced … WebNuclear translocation of AIF from mitochondria is a crucial event causing chromatinolysis in both apoptotic and necroptotic cells (2, 31). Within nuclei, AIF is recruited to λ-H2AX …
Chromatolysis definition of chromatolysis by Medical …
WebDec 26, 2024 · However, the depletion of these nucleases resulted in lower levels of chromatinolysis and cell death induced by MNNG, while the depletion of AIF was an absolute requirement to block caspase-independent cell death . Our work breaks away from this paradigm, providing compelling evidence that AIF Δ101 is endowed with nuclease … WebIn cellular neuroscience, chromatolysis is the dissolution of the Nissl bodies in the cell body of a neuron. It is an induced response of the cell usually triggered by axotomy, ischemia, … moulded baths
Chromatinolysis - definition of chromatinolysis by The Free …
WebAug 29, 2024 · Chromatinolysis is considered as one of the key events leading to cell death during necroptosis. It is usually accompanied with nuclear translocation of AIF and … WebApr 1, 2000 · Apoptosis inducing factor (AIF) is a novel apoptotic effector protein that induces chro-matin condensation and large-scale (—50 kbp) DNA fragmentation when added to purified nuclei in vitro. Confocal and electron microscopy reveal that, in normal cells, AIF is strictly confined to mitochondria and thus colocalizes with heat shock protein … Webnuclease domain blocked MIF nuclease activity and inhibited chromatinolysis, cell death induced by glutamate excitotoxicity, and focal stroke. Inhibition of MIF’s nuclease activity is a potential therapeutic target for diseases caused by excessive PARP-1 activation. P oly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is a nuclear enzyme that is ... moulded basin worktop