Tīmeklis2015. gada 2. nov. · One method to predict stereoinduction in asymmetric reactions is the Felkin-Anh model (derived from the more basic Cram model) that applies to nucleophile attacks on α-chiral … Tīmeklis2024. gada 3. febr. · Anti-Felkin–Anh diastereoselectivity can be achieved for nucleophilic additions to α-chiral ketones upon stretching the ketone with a mechanical pulling force. Herein, a mechanochemical Felkin–Anh model is proposed for predicting the outcome of a nucleophilic addition to an α-chiral ketone. Essentially, the fully …

Topic 12 Addition to π

Tīmeklis2024. gada 7. febr. · The present study demonstrates that the diastereoselectivity of the reaction can be inverted, using the rationale of a Felkin-Anh interaction model. Reactions performed on N,N-dibenzyl-L-phenylalaninal proceed with a high anti diastereoselectivity, providing a panel of synthetically useful ester derivatives of … TīmeklisFelkin-Anh is based on a reaction in which the metal and nucleophilic group both interact with the ends of the carbonyl bond simultaneously. They come together so … nbc 10 boston meteorologist staff

Chapter 34 — Diastereoselectivity - University of Victoria

TīmeklisHugh Felkin (* 18. Januar 1922 in Neuilly-sur-Seine, Département Seine; † 9. ... korrigierte eine Regel von Donald J. Cram und wurde in den 1970er Jahren von Nguyên Trong Anh und Odile Eisenstein zum Felkin-Anh-Modell erweitert. Mit diesem Thema befasste Felkin sich etwa von 1958 bis 1970. Tīmeklis2005. gada 2. maijs · Depending on the metal, solvent and protective groups, functionalized aldehydes may react through either Felkin or chelated transition states leading to the Felkin–Anh product or the 1,2-anti Felkin–Anh product, respectively.Zinc chloride addition proved to be a key aspect in order to favor 1,2-syn nucleophilic attack. nbc10 boston live stream