Glycogen phase separation and liver cancer
WebConsistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. Thus, we … WebNov 2, 2024 · A new study published in Cell suggests that glycogen can accumulate in the early stages of liver cancer, undergoing liquid–liquid phase separation (LLPS), disrupting the Hippo signalling pathway ...
Glycogen phase separation and liver cancer
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WebJul 30, 2012 · Liver cells normally produce glucose to help maintain healthy blood-sugar levels, but they lose that ability when they become cancerous, this study shows. This change might benefit tumor cells by helping them grow and proliferate. The study tracks how this loss happens and suggests that reversing it might offer a new way to treat this often ... WebApr 5, 2024 · Correlations between changes in phase separation and carcinogenesis only recently attracted the attention of researchers, and, now, growing evidence is accumulating that cancer-associated...
WebIn vitro and in vivo observations revealed that glycogen can spontaneously undergo LLPS, a process that has been proposed to underlie formation of membrane-less organelles and to establish whether eliminating glycogen accumulation can reduce liver tumour incidence. Expand 1 Save Alert Metabolic Reservoir Cycles in Cancer.
WebThus, we concluded that cancer-initiating cells adapt a glycogen storing mode, which blocks Hippo signaling through glycogen phase separation to augment tumor incidence. Original language: English (US) Pages (from-to) 5559-5576.e19: Journal: Cell: Volume: 184: Issue number: 22: ... Hippo signaling, liver cancer, Mst1, Mst2, phase separation", WebOct 21, 2024 · Europe PMC is an archive of life sciences journal literature.
WebOct 28, 2024 · Elimination of glycogen accumulation abrogates liver cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. ... Glycogen phase …
WebNov 1, 2014 · Consistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. … containers for drinksWebFeb 11, 2024 · Meanwhile, recent evidence that LLPS of glycogen can drive liver cancer initiation 90 potentially suggests much deeper links between LLPS and metabolic rewiring in cancer, highlighting the need ... containers for dry iceWebOct 6, 2024 · Glycogen phase separation drives liver tumor initiation: Organism: Mus musculus: Experiment type: ... Consistently, elimination of glycogen accumulation … containers for dryer sheetsWebDive into the research topics of 'Glycogen accumulation and phase separation drives liver tumor initiation'. Together they form a unique fingerprint. Sort by Weight Alphabetically Medicine & Life Sciences Glycogen Liver Glycogenolysis Neoplasms Carcinogenesis Glycogen Storage Disease Glycogen Phosphorylase Glucose-6-Phosphatase Liver … containers for dried herbsWebOct 30, 2024 · Introduction. Glycogen is a highly branched polymer of glucose that is used for the efficient storage and release of energy ().This function is highlighted by the … containers for drug testsWebConsistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. Thus, they concluded that cancer initiating cells adapt glycogen storing mode which blocks Hippo signaling through glycogen phase separation to augment tumor incidence. containers for drawersWebPhase separation refers to the phenomenon that when the concentration of solutes exceeds a certain threshold, known as the saturation concentration, the intermolecular force between biomacromolecules is bigger than that between biomacromolecules and the surrounding substances [ 1 ]. effect of cpi on stock market