WebPR:000010819 myogenic factor 6 (term hierarchy) InterPro Domains. IPR036638 Helix-loop-helix DNA-binding domain superfamily. IPR011598 Myc-type, basic helix-loop-helix (bHLH) … WebAdditionally lists of up- and downregulated robust DETFs sorted by PPI degree are presented (Figure 6c). Several known myogenic factors (STAT3, MEF2C, MYOG, MEF2A, MEF2D, MYF6, and NR4A1) [3,4,5,6,7,9,10] and functionally ambiguous factors (MAF, BCL6, and ESR1) were at the core of upregulated robust DETFs.
Myogenin
WebSep 23, 2004 · Two determination factors of the basic helix-loop-helix myogenic regulatory factor (MRF) family, Myf5 and Myod, are thought to direct this transition because double-mutant mice totally lack skeletal muscle fibres and myoblasts. In the absence of these factors, progenitor cells remain multipotent and can change their fate. WebDec 13, 2013 · Myogenic determination factor 1 (MyoD1) and myogenic factor 6 (Myf6) genes belong to the myogenic differentiation (MyoD) gene family, which play key roles in growth and muscle development.... roadhouse athens ohio
The circuitry of a master switch: Myod and the regulation of …
WebFeb 1, 1996 · The role of the four myogenic regulating genes Myf-5, myogenin, MyoD, and MRF4 (herculin, Myf-6) during mouse embryogenesis has been investigated by targeted gene inactivation. Null mutations for the MyoD gene generate no skeletal muscle phenotype due to a compensatory activation of the Myf-5 gene. WebHowever, mice in which Myog was deleted following embryonic muscle development had normal skeletal muscle, except for modest alterations in the levels of transcripts encoding Mrf4 (Myf6) and Myod1 (MyoD). Notably, Myog-deleted mice were 30% smaller than control mice, suggesting that the absence of myogenin disrupted general body growth. WebFeb 5, 2024 · Transforming growth factor β (TGFβ) is a pluripotent cytokine and regulates a myriad of biological processes. It has been established that TGFβ potently inhibits skeletal muscle differentiation; however, the molecular mechanism is not clearly defined. Previously, we reported that inhibition of the TGFβ canonical pathway by an inhibitory Smad, Smad7, … roadhouse at bottoms up