WebThe suppression of autophagy by mTORC1 may also contribute to the onset of senescence, in that palbociclib appears to induce reactive oxygen species [Citation 8] … WebApr 12, 2024 · This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who are found to harbor disseminated tumor cells (DTCs) in the bone marrow after definitive surgery and standard adjuvant therapy. Detailed Description:

The Intricate Interplay between Cell Cycle Regulators and Autophagy …

WebP53 pathway is a major determinant in the radiosensitizing effect of Palbociclib: Implication in cancer therapy Cancer Lett 1 de junio de 2024 ... Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance. Oncotarget 2015 WebNov 26, 2024 · In NPC cells, concurrent palbociclib treatment mitigated the cytotoxic effect of cisplatin in vitro. Notably, concurrent treatment with palbociclib and SAHA synergistically promoted NPC cell death both in vitro and in vivo. This combination also further inhibited … low poly ship blueprints

Palbociclib in Patients With Pancreatic and Biliary Cancer With WebAug 14, 2024 · Patients treated with palbociclib received standard doses (125 mg orally daily for 21 days followed by 7 days off treatment to complete a 28-day cycle) until disease progression. Radiographic tumor evaluations were performed at 8 and 16 weeks after treatment initiation. https://ascopubs.org/doi/10.1200/PO.19.00124 Phase I safety and efficacy study of autophagy inhibition with ... WebMay 28, 2024 · High concentrations of palbociclib induce senescence, but these are off target effects of the drug. The autophagy inhibitor hydroxychloroquine (HCQ) induces … https://ascopubs.org/doi/abs/10.1200/JCO.2024.39.15_suppl.1067 Palbociclib-induced autophagy and senescence in … WebNov 15, 2024 · However, whether or not this response is accompanied by induction of autophagy seems to depend on both the pRB and p53 status. In cells retaining … https://pubmed.ncbi.nlm.nih.gov/28947133/ The role of autophagy in resistance to targeted therapies WebAug 1, 2024 · Autophagy is a self-degradative cellular process, involved in stress response such as starvation, hypoxia, and oxidative stress. This mechanism balances macro … https://www.sciencedirect.com/science/article/pii/S0305737220300815 Inhibition of CDK4/6 and autophagy synergistically induces ... - PubMed WebInhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells Int J Hematol. ... AML cells had lower IC50 values for the selective CDK4/6 inhibitors palbociclib and abemaciclib than non-t(8;21) AML cells. CDK4/6 inhibitors caused cell cycle arrest at G1 phase and impaired cell proliferation in t(8 ... https://pubmed.ncbi.nlm.nih.gov/33068248/ Autophagy and Breast Cancer: Connected in Growth, … WebApr 14, 2024 · Autophagy can be cytoprotective (enhances cell survival), cytostatic (leads to growth arrest), cytotoxic (causes cell death), or nonprotective (no impact on cell death or cell survival). ... Palbociclib, and Ribociclib [196,197]. It is recognized that CDK4/6 inhibitors promote autophagy in various cancer models, ... https://advantx.org/autophagy-and-breast-cancer-connected-in-growth-progression-and-therapy/ (PDF) Palbociclib-induced autophagy and senescence in gastric … WebHowever, whether or not this response is accompanied by induction of autophagy seems to depend on both the pRB and p53 status. In cells retaining expression of both tumor sup- … https://www.academia.edu/92658770/Palbociclib_induced_autophagy_and_senescence_in_gastric_cancer_cells Lysosomal trapping of palbociclib and its functional implications WebJan 28, 2024 · Palbociclib is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) approved for the treatment of some cancers. The main mechanism of action of palbociclib is to induce cell cycle... https://www.nature.com/articles/s41388-019-0695-8 Palbociclib Induces Senescence in Melanoma and Breast Cancer … WebOct 13, 2024 · Palbociclib induces permanent G0/G1 cell cycle arrest by inducing senescence in fibroblasts, breast cancer, and melanoma cells. Direct cell death induction is only a minor secondary mechanism of action. Concomitant KI and radiotherapy is a strategy worth studying in clinical trials. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548830/ Palbociclib-induced autophagy and senescence in … WebNov 15, 2024 · Autophagy induction in gastric cancer cells exposed to Palbociclib. (A) Western blot analysis for LC3B-I, LC3B-II and p62, in AGS cells treated with 0.5 μM of … https://www.sciencedirect.com/science/article/pii/S0014482717305116 Cells Free Full-Text Autophagy and Breast Cancer: Connected … WebApr 14, 2024 · Autophagy is a highly conserved process that functions to transport cargos to the lysosome for recycling and cellular degradation in eukaryotes [].Autophagy not … https://www.mdpi.com/2073-4409/12/8/1156 Efficacy of a combination therapy targeting CDK4/6 and autophagy … WebAug 13, 2024 · The mice were treated with the autophagy inhibitor chloroquine (CQ), a CDK4/6 inhibitor (either abemaciclib or palbociclib), or a CDK4/6 inhibitor plus CQ. After 20 days of treatment, tumor volume was measured, and immunostaining and transmission electron microscopy observations were performed. There was no change in tumor … https://pubmed.ncbi.nlm.nih.gov/34430715/ Alfredo Smiriglia - PhD student - Università degli Studi di Firenze ... WebProject: "Glucose metabolic reprogramming in response and resistance to Palbociclib in ER+ breast cancer" Formazione Università degli Studi di Firenze Master’s Degree, Medical Biotechnology LM-9 110/ ... Thesis project: "The role of autophagy in endocrine therapy resistance of ER+ breast cancer" Mentor: Prof.ssa Elisa Giannoni https://it.linkedin.com/in/alfredo-smiriglia-670310198 The Intricate Interplay between Cell Cycle Regulators and Autophagy … WebDec 29, 2024 · Similarly, palbociclib also induces autophagy and cellular senescence in Rb-positive cytoplasmic cyclin E negative cancers . Two recent studies investigated the importance of CDK4/6 coupling cell-cycle progression and the cell growth of breast cancer cells [57,58]. cyclinD-CDK4/6 regulates both the activation and localization of mTORC1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750274/

WebSep 1, 2024 · The cdk4/6 inhibitor, Palbociclib, induced p53-dependent autophagy in gastric cancer cells, and the knockdown of p53 was accompanied by a deficiency of the lysosome-mediated degradation of... WebAutophagy is a stress tolerance mechanism in cancer, which promotes the degradation of cell components by fusing cell components with lysosomes and provides energy for survival. 66 Autophagy is an important drug resistance mechanism that occurs with many cancer-targeting agents, including palbociclib, which has been shown to induce reactive ... WebJan 28, 2024 · Palbociclib (also known as PD-0332991) is a highly selective CDK4/6 inhibitor approved for the treatment of advanced or metastasized estrogen receptor (ER) … javascript check checkbox checked or not